A model study of the tubuloglomerular feedback mechanism: effector site and influence on renal autoregulation

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Abstract
The effector site of the macula densa tubuloglomerular feedback mechanism was determined with a mathematical model of glomerular ultrafiltration. The feedback response was mediated by an increase in the hydraulic resistance of the afferent arteriole, possibly accompanied by a slight decrease in the ultrafiltration coefficient of the glomerular membrane. The contribution of the tubuloglomerular feedback mechanism to the autoregulation of renal blood flow and GFR [glomerular filtration rate] during increased arterial blood pressure was evaluated with a mathematical model of the kidney. The tubuloglomerular feedback system of the superficial nephron was a less efficient regulator of renal blood flow and GFR than the remainder of the autoregulatory mechanism.