Does calcium mediate the slowing of gastric emptying in primates?

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Abstract
EDTA (1 g/l) in test meals of water slowed gastric emptying strongly in 1 human and 4 rhesus monkeys. When the binding sites of the EDTA were loaded with Ca before it was given in the test meal, there was little effect on gastric emptying. EDTA probably takes up Ca from the tight junctions of the duodenal epithelium. As a result, a signal is set up that slows gastric emptying. The anions of fatty acids produced during the digestion of triglycerides in the duodenum may also slow gastric emptying by the same mechanism. The means by which fats, carbohydrates and proteins could all slow gastric emptying by operating on the same receptor, is explained.