Cell Proliferation of Canine Cyclic Hematopoietic Marrow in Diffusion Chambers

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Abstract
The ability (cytopoietic potential) of marrow from dogs with cyclic hematopoiesis to proliferate within diffusion chambers that were implanted into irradiated mice was studied. Cytopoietic potentials fluctuated over the hematopoietic cycle from near normal levels during the period of peripheral neutropenia to significantly below normal when peripheral blood neutrophils were elevated. A compromised multipotential stem cell compartment probably occurs during cyclic hematopoiesis. Periodic proliferation of these stem cells may account for the previously recognized in-phase cycling of committed granulocytic and erythrocytic progenitor cells.