Abnormal Ca2+-ATPase Activity in Erythrocytes of Non-Insulin-Dependent Diabetic Rats
- 14 March 1990
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 22 (03) , 136-140
- https://doi.org/10.1055/s-2007-1004870
Abstract
Non-insulin-dependent diabetic (NIDD) rats have an increased Ca2+-ATPase activity in their kidney basolateral membranes. We find that a similar increased activity occurs in erythrocytes of the NIDD animals. This alteration in membrane ATPase activity appears to be specific for the Ca2+-ATPase as (Na+ + K+) and Mg2+-ATPase and Na, K and Mg concentrations in the erythrocyte were not affected by the diabetic condition in these animals. Thus, abnormalities in membrane Ca2+-ATPase activity in the NIDD rats are not restricted to one tissue and appear to be a generalized pathology in the NIDD animals.Keywords
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