STUDIES OF THE MECHANISM OF THE EFFECT OF HOG INTRINSIC FACTOR CONCENTRATE ON THE UPTAKE OF VITAMIN B12 BY RAT LIVER SLICES1
Open Access
- 1 May 1958
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 37 (5) , 646-650
- https://doi.org/10.1172/jci103648
Abstract
Vitamin B12 uptake by rat liver slices is enhanced markedly in the presence of appropriate concentrations of hog intrinsic factor concentrate. This enchancement is observable at 37.5[degree]C, at 3[degree]C, and in the presence of 10-4[image] 2,4-dinitrophenol. It requires calcium (or strontium), and is reversible to an appreciable extent by ethylenediaminetetraacetate. These findings suggest the mechanism is physical rather than metabolic.Keywords
This publication has 4 references indexed in Scilit:
- Potassium uptake of Alcaligenes faecalisBiochemical Journal, 1957
- An Improved Urinary Excretion Test as an Assay for Intrinsic Factor.Experimental Biology and Medicine, 1955
- STUDIES ON CARBOHYDRATE METABOLISM IN RAT LIVER SLICES .1. THE EFFECT OF CATIONS IN THE MEDIA1952
- Buffers in the Range of pH 6.5 to 9.6.Experimental Biology and Medicine, 1946