Total Synthesis of Eupomatilones 4 and 6: Structurally Rearranged and Atropisomerically Fluxional Lignan Natural Products

1 October 2004

journal article
research article
Published by American Chemical Society (ACS) in Organic Letters

Vol. 6 (22) , 4025-4028
https://doi.org/10.1021/ol048333e

Abstract

A convergent and diastereocontrolled total synthesis of eupomatilones 4 and 6 is reported and was based on a diastereoselective hydroboration/oxidation sequence and a convergent Lipshutz biarylcuprate cross-coupling reaction. The structure of eupomatilone 6 is revised.

Keywords

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