Early Chemical Evolution of Nucleic Acids: A Theoretical Model
- 15 April 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 196 (4287) , 311-313
- https://doi.org/10.1126/science.583625
Abstract
Recent experimental work suggests a possible cyclical pathway for early prebiotic oligonucleotide formation that involves (i) dry-state (nontemplate) synthesis of random copolymers with mixed 2',5' and 3',5' bonds, (ii) passage of these oligomers into solution at low temperatures, and (iii) a preferential hydrolysis of the 2',5' bond in any short helices that have formed. This early system could have selected for complementary sequences that were largely 3',5'-linked, but may not have selected efficiently for a single enantiomer of ribose.This publication has 13 references indexed in Scilit:
- Nonenzymic Joining of Oligoadenylates on a Polyuridylic Acid TemplateScience, 1976
- Prebiotic chemistry and nucleic acid replicationAccounts of Chemical Research, 1974
- Stability of ribonucleic acid double-stranded helicesJournal of Molecular Biology, 1974
- Self‐Organization of Molecular Systems and Evolution of the Genetic ApparatusAngewandte Chemie International Edition in English, 1972
- Earth and Mars: Evolution of Atmospheres and Surface TemperaturesScience, 1972
- Prebiotic Phosphorylation of Thymidine at 65° C in Simulated Desert ConditionsNature, 1972
- Chemical evolution. IV. Evaluation of cyanovinyl phosphate as a prebiotic phosphorylating agentJournal of the American Chemical Society, 1970
- Conformation and interaction of dinucleoside mono- and diphosphates. 3. L-adenylyl-(3'-5')-L-adenosine and L-adenylyl-(2'-5')-L-adenosineBiochemistry, 1970
- Specificity of template-directed synthesis with adenine nucleosidesJournal of Molecular Biology, 1970
- 13. Nucleotides. Part X. Some observations on the structure and chemical behaviour of the nucleic acidsJournal of the Chemical Society, 1952