Clonal Spread of mef -Positive Macrolide-Resistant Streptococcus pneumoniae Isolates Causing Invasive Disease in Adults in Germany
- 1 May 2007
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 51 (5) , 1830-1834
- https://doi.org/10.1128/aac.01453-06
Abstract
Isolates (3,845) obtained from German adults with invasive pneumococcal disease between 1992 and 2004 were investigated. Of these, 430 isolates (11.2%) were erythromycin A nonsusceptible. Macrolide resistance genotypes and multilocus sequence types were determined. Among the isolates, 35.6% were erm (B) positive and 63.5% were mef positive. Over the study period, the frequency of resistance rose significantly from 2.2 to 17.0% ( P < 0.001). A serotype 14, sequence type 9 clone was the most widespread.Keywords
This publication has 20 references indexed in Scilit:
- Increase of the M Phenotype among Erythromycin-Resistant Streptococcus pneumoniae Isolates from Spain Related to the Serotype 14 Variant of the Spain 9V -3 CloneAntimicrobial Agents and Chemotherapy, 2006
- Erythromycin-nonsusceptibleStreptococcus pneumoniaein Children, 1999–2001Emerging Infectious Diseases, 2005
- Emergence and Spread ofStreptococcus pneumoniaewitherm(B) andmef(A) ResistanceEmerging Infectious Diseases, 2005
- Molecular Epidemiology of Macrolide-Resistant Streptococcus pneumoniae Isolates in EuropeJournal of Clinical Microbiology, 2005
- Invasive Streptococcus pneumoniae in France: Antimicrobial Resistance, Serotype, and Molecular Epidemiology Findings from a Monthly National Study in 2000 to 2002Antimicrobial Agents and Chemotherapy, 2004
- Clinical efficacy of ketolides in the treatment of respiratory tract infectionsJournal of Antimicrobial Chemotherapy, 2004
- Molecular Epidemiology of Erythromycin Resistance in Streptococcus pneumoniae Isolates from Blood and Noninvasive SitesJournal of Clinical Microbiology, 2002
- Differentiation of Resistance Phenotypes among Erythromycin-Resistant PneumococciJournal of Clinical Microbiology, 2001
- Mutations in 23S rRNA and Ribosomal Protein L4 Account for Resistance in Pneumococcal Strains Selected In Vitro by Macrolide PassageAntimicrobial Agents and Chemotherapy, 2000
- A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive diseaseMicrobiology, 1998