HUMORAL IMMUNITY AGAINST VIRAL-ANTIGENS IN INSULIN-DEPENDENT DIABETES-MELLITUS (IDDM) - ALTERED IGA CLASS IMMUNE-RESPONSE AGAINST MUMPS-VIRUS
- 1 January 1985
- journal article
- research article
- Vol. 60 (1) , 139-144
Abstract
Two hundred and ten pediatric insulin-dependent diabetes mellitus (IDDM) patients with long duration of illness and their matched controls (age range 2-19 yr) were analyzed for mumps antibodies in IgG, IgM and IgA antibody classes by enzyme linked immunosorbent assay (ELISA). About 70% of both patients and controls had antibodies against mumps virus. IDDM patients had higher mean levels of IgA class antibodies than the controls, while no difference was found in IgG or IgM class antibodies. The elevated IgA class mumps antibodies did not correlate with elevated levels of IgA class coxsackie virus B4 or cytomegalovirus antibodies. This elevation of IgA antibody levels was evident already early after mumps infection and seemed to persist several years, since the difference was most pronounced in the oldest age group. Female patients as well as female controls had significantly higher IgG and IgM antibody levels compared to males. This may at least in part be explained by a difference in the age distribution in females compared to males and may suggest different age-dependent epidemiology of mumps between boys and girls in this material. No such difference was found in IgA levels between the sexes.This publication has 15 references indexed in Scilit:
- Determination of IgG, IgM and IgA Antibody Responses in Human Toxoplasmosis by Enzyme-Linked Immunosorbent Assay (ELISA)Scandinavian Journal of Infectious Diseases, 1983
- Insulin-Dependent Diabetes Mellitus: The Initial LesionNew England Journal of Medicine, 1981
- Virus-induced diabetes mellitus. XVIII. Inhibition by a nondiabetogenic variant of encephalomyocarditis virus.The Journal of Experimental Medicine, 1980
- Relation of antecedent illness to development of diabetes in children.BMJ, 1980
- Genetic patterns in diabetes mellitusHuman Pathology, 1980
- COMPLEMENT-FIXING ISLET-CELL ANTIBODIES IN TYPE-I DIABETES - POSSIBLE MONITORS OF ACTIVE BETA-CELL DAMAGE1980
- Evaluation of Enzyme-Linked Immunosorbent Assay (ELISA) for Mumps Virus AntibodiesExperimental Biology and Medicine, 1979
- DETERMINATION OF VIRUS-SPECIFIC IGM ANTIBODIES BY USING ELISA - ELIMINATION OF FALSE-POSITIVE RESULTS WITH PROTEIN-A-SEPHAROSE ABSORPTION AND SUBSEQUENT IGM ANTIBODY ASSAY1978
- Virus-induced diabetes mellitusArchiv für die gesamte Virusforschung, 1977
- Coxsackie Viruses and Diabetes MellitusBMJ, 1973