How Common Is Reye's Syndrome?

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Abstract
Twenty years ago, the seminal report by Reye et al. drew attention to "encephalopathy with fatty degeneration of the viscera."1 This clinical entity, now recognized throughout the world, is a major cause of noninfectious neurologic death after viral illness in children.2 The clinical syndrome is composed of two phases: an infectious phase followed within a few days by an encephalopathic phase. Influenza B or A and varicella account for most of the infections. The temporal constancy between the two phases is remarkable. Recurrent vomiting begins about five or six days after the onset of the infectious symptoms. The vomiting may . . .