Abstract
Drinking habits and other characteristics were observed for 20 yr in a cohort of 5209 Framingham men and women. The average amount of alcohol consumed rose 63%. The percent increase was greater for women and greater for younger persons. Serum uric acid and phospholipid concentrations were higher at higher levels of alcohol consumption. Lipoprotein levels of 0-12 and 100-400 Svedberg U were positively associated with alcohol consumption in men but negatively associated with alcohol consumption in women. Blood pressure [BP] was higher in nondrinkers than light drinkers, but among drinkers BP was higher at higher consumption levels. While cigarette smokers had lower BP than nonsmokers, this seemed to be due to their lower weight. Persons who increased their alcohol consumption during follow-up had a small mean increase in serum phospholipid and uric acid levels, BP and weight relative to the average changes for these variables.