THE EFFECT OF THYROID HORMONES ON THE URINARY EXCRETION OF TAURINE IN MAN

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Abstract
The urinary excretion of taurine has been determined for six hypothyroid patients before and after therapeutic treatment with thyroid hormones. Three of the patients were fed a standardized diet in isocaloric amounts during both parts of the study, whereas the other subjects were given the hospital diet without restriction. Duodenal bile, collected from three patients, was analysed for bile acids. After therapy the urinary taurine increased in all patients and the elevated ratio between glycine and taurine conjugated bile acids dropped towards a normal range. Treatment with thyroid hormones did not influence the urinary excretion of sulphate in two of three patients studied. It was concluded that the effect of treatment on the excretion of taurine in hypothyroid patients was not due to an elevated intake of sulphuramino acids with the diet.