QUANTITATIVE STUDY OF THE EFFECTS OF ESTRADIOL BENZOATE AND PROGESTERONE IN MODIFYING THE INCIDENCE OF BINUCLEATED CELLS IN THE RABBIT LIVER

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Abstract
Castration led to a significant reduction in the incidence of binucleated cells. Sesame oil alone increased the number of binucleated cells both in normal and castrated rabbits. Estrogen and progesterone, given singly or together, increased the incidence of binucleated cells, and progesterone plus estradiol benzoate proved especially effective. Whether the liver inactivates or excretes estradiol benzoate and progesterone, these activities are not achieved without affecting the nuclei of the liver cells, and in a manner different to that described for the epithelial cells of the uterus and vagina.