The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo
- 1 August 1999
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 2 (8) , 699-705
- https://doi.org/10.1038/11158
Abstract
To determine the role of the p75 neurotrophin receptor (p75NTR) in sympathetic neuron development, we crossed transgenic mice with mutations in p75NTR, nerve growth factor (NGF) and neurotrophin-3 (NT-3). Neuron number is normal in sympathetic ganglia of adult p75NTR–/– mice. Mice heterozygous for a NGF deletion (NGF+/–) have 50% fewer sympathetic neurons. In the absence of p75NTR (p75NTR–/– NGF+/–), however, neuron number is restored to wild-type levels. When NT-3 levels are reduced (p75NTR–/– NGF+/– NT3 +/–), neuron number decreases compared to p75NTR–/– NGF+/– NT3+/+. Thus, without p75NTR, NT3 substitutes for NGF, suggesting that p75 alters the neurotrophin specificity of TrkA in vivo.Keywords
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