Structure and mapping of thefosB gene. FosB downregulates the activity of thefosB promotero
Open Access
- 1 January 1992
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 20 (2) , 343-350
- https://doi.org/10.1093/nar/20.2.343
Abstract
We have determined the genomic structure of the fosB gene and shown that it consists of 4 exons and 3 introns at positions also found in the c-fos gene. By deletion analysis we have characterized a region upstream of the TATA box which is the promoter region of the gene. Several consensus sequences have been identified, including an SRE and AP-1 binding site whose relative positions are identical to those in the 5'upstream region of the c-fos gene. We have also shown that FosB and c-Fos can downregulate the activity of the fosB promoter to a similar extent. The fosB gene is located in the [A1-B1] region of mouse chromosome 7.Keywords
This publication has 53 references indexed in Scilit:
- PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERSAnnual Review of Biochemistry, 1991
- Trans-repression of the mouse c-fos promoter: A novel mechanism of fos-mediated trans-regulationCell, 1989
- Structure, chromosome mapping and regulation of the mouse zinc-finger gene Krox-24; evidence for a common regulatory pathway for immediate-early serum-response genesGene, 1989
- Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.Genes & Development, 1988
- The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genesCell, 1988
- Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblastsNature, 1988
- The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding SitesScience, 1988
- Induction of c-fos gene and protein by growth factors precedes activation of c-mycNature, 1984
- Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogeneNature, 1984
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977