BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT

This publication has 8 references indexed in Scilit:

• A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES
  Drug Metabolism and Disposition, 2005
• THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES
  Drug Metabolism and Disposition, 2005
• QUANTITATIVE PREDICTION OF THE IN VIVO INHIBITION OF DIAZEPAM METABOLISM BY OMEPRAZOLE USING RAT LIVER MICROSOMES AND HEPATOCYTES
  Drug Metabolism and Disposition, 2004
• THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE
  Drug Metabolism and Disposition, 2003
• The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
  Drug Metabolism and Disposition, 2002
• In Vitro Analysis of Human Drug Glucuronidation and Prediction of in Vivo Metabolic Clearance
  The Journal of Pharmacology and Experimental Therapeutics, 2002
• Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential-toward a consensus
  Clinical Pharmacology & Therapeutics, 2001
• Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  Drug Metabolism and Disposition, 1999