Further Observations of Certain Responses of Tolerant and Control Animals to Massive Doses of Epinephrine

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Abstract
Since dogs that were able to survive doses of 3 mg. of neosynephrine were not killed by a surely lethal dose (0.8 mg./kg. body wt.) of epinephrine, it is evident that the tolerance is nonspecific. The response of the blood pressure of dogs to 0.005 mg. of epinephrine/kg. was the same before and after tolerance to 3.0 mg. of epinephrine/kg. was acquired. The rectal temp. of large dogs may be increased to as much as 4.5[degree]C. more than the control temp. by an infusion of epinephrine continued until the death of the animal. In contrast, the rectal temp. of small dogs may be depressed to as much as 5.9[degree]C less than control temps. Similar results were obtained with neosynephrine. Dogs that received 1.5 mg. of epinephrine twice weekly for 3 yrs. and 7 mos. did not show at time of death pathologic effects as a result of this treatment that were different from those seen in dogs killed by a single dose of the drug.

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