Curcumin as a DNA Topoisomerase II Poison
- 1 December 2003
- journal article
- Published by Taylor & Francis in Journal of Enzyme Inhibition and Medicinal Chemistry
- Vol. 18 (6) , 505-509
- https://doi.org/10.1080/14756360310001613085
Abstract
Curcumin, the major active component of the spice turmeric, is recognised as a safe compound with great potential for cancer chemoprevention and cancer therapy. It induces apoptosis, but its initiation mechanism remains poorly understood. Curcumin has been assessed on the human cancer cell lines, TK-10, MCF-7 and UACC-62, and their IC50 values were 12.16, 3.63, 4.28 microM respectively. The possibility of this compound being a topoisomerase II poison has also been studied and it was found that 50 microM of curcumin is active in a similar fashion to the antineoplastic agent etoposide. These results point to DNA damage induced by topoisomerase II poisoning as a possible mechanism by which curcumin initiates apoptosis, and increase the evidence suggesting its possible use in cancer therapy.Keywords
This publication has 30 references indexed in Scilit:
- Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosisBlood, 2003
- Effect of Curcumin on the Apoptosis of Rodent and Human Nonproliferating and Proliferating Lymphoid CellsNutrition and Cancer, 2000
- Recent studies on the biofunctions and biotransformations of curcuminBioFactors, 2000
- Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cellsBritish Journal of Pharmacology, 1998
- Human Topoisomerase II Function, Tyrosine Phosphorylation and Cell Cycle CheckpointsExperimental Biology and Medicine, 1998
- Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cellsBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1996
- Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoidsMutation Research/Genetic Toxicology, 1996
- Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell linesNutrition and Cancer, 1996
- Strategy and planning for chemopreventive drug development: Clinical development plans IIJournal of Cellular Biochemistry, 1996
- DNA TOPOISOMERASESAnnual Review of Biochemistry, 1985