Specificity Spillover at the Hormone Receptor — Exploring Its Role in Human Disease
- 9 March 1989
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 320 (10) , 640-645
- https://doi.org/10.1056/nejm198903093201005
Abstract
IN some disease states, one or more manifestations of hormonal excess may be caused by the interaction of one hormone with the receptor for a different hormone. When one receptor is activated by a signal designed for another, the event is termed a "specificity spillover."1 , 2 Such a spillover, or cross reaction, is not random, but occurs between two hormones with a similar structure. The effects observed are determined not by the hormone that is present, but by the receptor that is activated. A given hormone has a primary affinity for its own receptor, but it may also retain an affinity . . .Keywords
This publication has 44 references indexed in Scilit:
- Synthesis and Secretion of Insulin-like Growth Factor II by a Leiomyosarcoma with Associated HypoglycemiaNew England Journal of Medicine, 1988
- Dual regulation of glycogen metabolism by insulin and insulin-like growth factors in human hepatoma cells (HEP-G2). Analysis with an anti-receptor monoclonal antibody.Journal of Clinical Investigation, 1984
- Human growth hormone but not ovine or bovine growth hormones exhibits galactopoietic prolactin-like activity in organ culture from bovine lactating mammary glandMolecular and Cellular Endocrinology, 1983
- Down-regulation of prolactin receptors in the liver, mammary gland and kidney of female virgin rat, infused with ovine prolactin or human growth hormoneBiochemical and Biophysical Research Communications, 1983
- Hypoglycemia Associated with Non-Islet-Cell Tumor and Insulin-like Growth FactorsNew England Journal of Medicine, 1982
- Photoactivated cross-linking of prolactin to hepatic membrane binding sitesBiochemical and Biophysical Research Communications, 1982
- Hypoglycemia Associated with Non-Islet-Cell Tumor and Insulin-like Growth FactorsNew England Journal of Medicine, 1981
- Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia.Journal of Clinical Investigation, 1981
- Pathogenesis of hypoglycemia in insulinoma patients: suppression of hepatic glucose production by insulinDiabetes, 1981
- Radioreceptor Assay for Prolactin and Other Lactogenic HormonesScience, 1973