Marineosins A and B, Cytotoxic Spiroaminals from a Marine-Derived Actinomycete
- 13 November 2008
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (24) , 5505-5508
- https://doi.org/10.1021/ol8020644
Abstract
Two novel spiroaminals, marineosins A and B (1, 2), containing two pyrrole functionalities, were isolated from cultures of a marine sediment-derived actinomycete related to the genus Streptomyces. The marineosins, which appear to be derived from unknown modifications of prodigiosin-like pigment pathways, showed significant inhibition of human colon carcinoma (HCT-116) in an in vitro assay (IC50 = 0.5 μM for marineosin A) and selective activities in diverse cancer cell types.Keywords
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