Fredericamycin A a new antitumor antibiotic. II. Biological properties.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (11) , 1402-1407
- https://doi.org/10.7164/antibiotics.34.1402
Abstract
Fredericamycin A is a novel antibiotic produced by a soil isolate of Streptomyces griseus (FCRC-48). In vitro, fredericamycin A exhibits antibacterial, antifungal and cytotoxic activities. In vivo fredericamycin A exhibits very good antitumor activity against P388 mouse leukemia and the CD8F mammary tumor and marginal activity against B16 melanoma. Fredericamycin A failed to demonstrate any interaction with DNA and inhibited protein and RNA synthesis preferentially to DNA synthesis in Bacillus subtilis and P388 cells.This publication has 1 reference indexed in Scilit:
- Uniform Production and Bulk Storage of P388 Murine Lymphoma Cells for Antitumor AssayExperimental Biology and Medicine, 1980