Amyloid Accumulation and Pathogensis of Alzheimer’s Disease: Significance of Monomeric, Oligomeric and Fibrillar Aβ
Top Cited Papers
- 1 January 2005
- book chapter
- Published by Springer Nature
- Vol. 38, 167-177
- https://doi.org/10.1007/0-387-23226-5_8
Abstract
This chapter reviews recent findings that indicate that soluble amyloid oligomers may represent the primary pathological species in Alzheimer’s and other degenerative diseases. Various amyloids share a number of common properties, including their structures and pathways for fibril formation and accumulation in disease. Recent findings suggest that toxic amyloid oligomers share a common structure, suggesting that they also share a common mechanism of pathogenesisKeywords
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