Guillain-Barré Syndrome with Slow Progressive Onset and Persistent Elevation of Spinal Fluid Protein

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Abstract
Four patients are described in whom the clinical presentation of the Guillain-Barre syndrome caused by viral infection was one of slow progression as opposed to the acute onset generally observed. This chronic form represents a poorly appreciated and often misdiagnosed variation of the characteristic syndrome. In 2 of the patients, the cerebrospinal fluid protein content remained elevated for several years despite apparent return to good health, both subjectively and on examination. All of the patients were young (10, 13, 18, and 23). In 3 of the 4 patients, muscular dystrophy was diagnosed.

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