Cerebrospinal Pathology of Experimental Poliomyelitis in the Eastern Cotton Rat, Sigmodon hispidus hispidus, and in the White Mouse, Mus musculus

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Abstract
Intracerebral inoculation with the Lansing strain of poliomyelitis virus produces in cotton rats and white mice an inflammatory process characterized by necrosis of nerve cells, polymorphonuclear leucocyte exudation and invasion of necrotic cells, neuronophagia by macrophages, diffuse and focal cellular gliosis, vascular endotheliosis and sheath lymphocyte infiltration. In the brain the dorsal portion of the pons is most involved, then the medulla, midbrain, thalamus and cerebellar roof nuclei. Cerebral cortex in both spp. shows little involvement, most in the hippocampus. Corpora striata and cerebellar cortex show the least involvement. In spite of intracerebral inoculation into the thalamomesencephalic region, the earliest observed lesions are in the spinal cord in both spp. The process in both spp. resembles the reaction of poliomyelitis in man and monkeys. Vessel sheath lymphocyte infiltration is less in cotton rats than in mice, monkeys, or man.