Constitutional and Environmental Factors Related to Serum Lipid and Lipoprotein Levels

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Abstract
Serum lipoproteins and lipids were measured in 657 men (age 48) and were correlated with multiple constitutional and environmental variables. The 2 lipoprotein groups, Sf 0-12 and Sf 20-400, had a low inter correlation and each correlated with different factors. The Sf 0-12 lipoproteins were related to constitutional obesity, cigarette smoking, and family history of vascular disease. The Sf 20-100 and Sf 100-400 lipoproteins were related to acquired obesity, carbohydrate tolerance, and aggressiveness and sociability as determined by personality survey. Carbohydrate tolerance, obesity, and personality were apparently independent variables. Serum triglyceride levels correlated with the same variables as the Sf 20-400 lipoproteins; serum cholesterol levels were related to factors that correlated with both lipoprotein groups. High levels (above 90th percentile) of each lipoprotein fraction and each lipid were associated with significantly greater quantities of the variables found to be correlated with each lipid fraction. The prevalence of familial hyperlipidemias was low (approximately 3-4%), but 18% of individuals with elevated cholesterol and a high risk of coronary heart disease could be tentatively classified as having a type of familial hyperlipidemia.

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