Weight, Ascorbic Acid and Cholesterol Changes in Adrenals of Pyridoxine-Deficient Adult Male Rat

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Abstract
Two days after hypophysectomy, the pyridoxine-deficient rat treated with ACTH had the same amt. of adrenal ascorbic acid depletion and adrenal wt. increase as did pair-weighed and ad libitum controls but like these controls no decrease in adrenal cholesterol. When intact animals were subjected to hypoxia, the pyridoxine-deficient group, although able to maintain adrenal wts. and adrenal ascorbic acid content as did the pair-weighed and ad libitum groups, clearly failed to show the adrenal cholesterol depletion characteristic of the latter groups. The depletion of adrenal cholesterol is apparently not controlled by the same mechanism involved in adrenal hypertrophy and adrenal ascorbic acid depletion.