DELAYED HYPERSENSITIVITY TO HAPTEN-PROTEIN CONJUGATES

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Abstract
Guinea pigs were rendered delayed hypersensitive to conjugates of guinea pig serum albumin with simple chemical haptens. Related homologous series of haptens were employed, such as ortho-, meta-, and para-azobenzoates, benzene sulfonates, benzene arsonates, and nitrobenzenes. Skin tests were performed to estimate the extent of immunological cross-reactions among these antigenic conjugates before the appearance of circulating antibody. Delayed specificity was found to be a function of both the nature and position of the substituent in the benzene ring. The extent of cross-reactions was greater, however, . than that reported previously for rabbit antibody systems, which supports the concept of a functionally larger determinant in the delayed system than that required by conventional antibody. Desensitization studies indicate that the delayed response is characterized by the production of a heterogeneous population of sensitive cells directed toward the simple chemical hapten structure.

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