Replacement of a Phosphoenolpyruvate-dependent Phosphotransferase by a Nicotinamide Adenine Dinucleotide-linked Dehydrogenase for the Utilization of Mannitol

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Abstract
Mannitol is dissimilated by Aerobacter aerogenes via an inducible pathway initiated by a phos-photransferase system dependent upon phosphoenolpyruvate as the phosphoryl donor. A mutational block in this pathway can be suppressed either at the phenotypic level by induction of D-arabltol dehydrogenase, an enzyme fortuitously capable of converting manntiol to fructose or genotypically by a constitutive mutation in the D-arabltol system.