Comparison of calcitonin, epinephrine and glucagon effects on plasma membrane Ca-ATPase activity and calcium content in liver of rats.

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Abstract
The effects of calcitonin (CT), epinephrine and glucagon on the plasma membrane Ca-ATPase activity and the CA content in the liver were investigated 30 min after a single s.c. administration of hormones to rats. Ca-ATPase activity in the plasma membrane fraction was significantly decreased by CT (Medical Research Council mU/100 g BW [body wt]) while not being significantly lowered by insulin (100 mU/100 g BW), epinephrine (100 .mu.g/100 g BW), glucagon (50 .mu.g/100 g BW), or parathyroid hormone (25 U/100 g BW). The Ca content in the liver was markedly increased by CT, while not being significantly elevated by epinephrine or glucagon. Meanwhile, the decrease of Ca-ATPase activity in the plasma membrane fraction produced by CT was significantly prevented by simultaneous administration of epinephrine or glucagon. The increase in liver Ca was also noticeably interfered with. The action of CT on liver CA may differ from that of epinephrine or glucagon, which causes an increase in cAMP in the liver cells.