Effects of calcitonin and other hormones on bile calcium excretion in thyroparathyroidectomized rats.

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Abstract
The effects of calcitonin (CT) and other hormones on the bile Ca excretion after a single i.p. administration of Ca (4.0 mg/100 g BW [body wt]) was investigated in thyroparathyroidectomized rats. Porcine, salmon and synthetic ell CT (80 MRC[mouse radius calcifying]m U[units]/100 g BW, respectively) markedly increased the bile Ca excretion in comparison with that of Ca-administered rats. Tetragastrin (7.5 .mu.g/100 g BW), and insulin (50 mU/100 g BW) did not significantly alter the bile Ca excretion, while epinephrine (100 .mu.g/100 g BW), glucagon (50 .mu.g/100 g BW) and parathyroid hormone (25 U/100 g BW) increased significantly. The increasable effect of CT on the bile Ca excretion was significantly prevented by epinephrine (10 and 100 .mu.g/100 g BW). The bile Ca excretion may be increased by the hormones which causes the elevation of cyclic AMP in the liver cells of rats.