Radiosensitization of Tumor Cells

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Abstract
To the Editor: The editorial, "Hypoxic Cell Radiosensitizers,"1 emphasized the need to develop more efficient but less toxic electron-affinic drugs as radiosensitizers. However, whereas metronidazole is indeed electron affinic as compared to a biomolecule such as carbon dioxide, this is a relative term, and the sensitizing action of the compound can be more closely associated with its constituent nitro group.2 , 3 Although other nitro compounds are under investigation we believe that the use of drugs of higher electron affinity of this type will carry an increased risk of sensitizing normal tissues. Some electron-affinic compounds sensitize fully oxygenated cells although to . . .

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