Modularity and evolutionary constraint on proteins

6 March 2005

journal article
research article
Published by Springer Nature in Nature Genetics

Vol. 37 (4) , 351-352
https://doi.org/10.1038/ng1530

Abstract

Modularity, which has been found in the functional and physical protein interaction networks of many organisms, has been postulated to affect both the mode and tempo of evolution. Here I show that in the yeast Saccharomyces cerevisiae, protein interaction hubs situated in single modules are highly constrained, whereas those connecting different modules are more plastic. This pattern of change could reflect a tendency for evolutionary innovations to occur by altering the proteins and interactions between rather than within modules, in a manner somewhat similar to the evolution of new proteins through the shuffling of conserved protein domains.

Keywords

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