LARGE DOSES OF PROPYLTHIOURACIL IN THE TREATMENT OF HYPERTHYROIDISM*

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Abstract
Twenty-four patients with hyperthyroidism (primary in 12, and associated with adenomatous goiter in 12) were given propylthiouracil in doses ranging from 600 to 1000 mg daily. It was found that doses as high as 1000 mg daily could be used with comparative safety, as the incidence of reactions was not prohibitive. There were only 2 reactions in the 24 patients, and in neither case was the reaction serious. No instance of adverse effect on the blood cells was noted. The response to large-dose therapy in the patients with adenomatous goiter was not striking; but an enhanced response was observed in patients with thyrocardiac disease, and therefore such therapy is particularly indicated in this group. The patients with primary hyperthyroidism showed a dramatic and rapid response to large doses.

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