A RELATIONSHIP BETWEEN ESTROGEN SULFURYLATION AND ESTROGEN AND PROGESTERONE-RECEPTOR STATUS IN HUMAN MAMMARY-CARCINOMA

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (4) , 1360-1362
Abstract
It was previously demonstrated that a correlation existed between estrogen receptor (ER) status and levels of estrogen sulfotransferase in human mammary cancer, high levels bine associated with ER-positive and low levels with ER-negative tumors. These parameters were examined along with progesterone receptor (PGR) status in 44 primary human mammary tumors. Tumors which were ER-positive and PGR-positive (n [sample size] = 21) showed significantly higher levels of estrogen sulfotransferase compared to ER-positive PGR-negative (n = 12) and ER-negative PGR-negative (n = 11) tumors. These values (pmol estradiol sulfate per mg protein per 2 h) were 72 .+-. 12 (SE), 25 .+-. 5, and 11 .+-. 4 (P < 0.01 and < 0.005, respectively). There was no significant difference between ER-positive PGR-negative and ER-negative PGR-negative tumors. The possible involvement of PGR in the regulation of estrogen sulfotransferase is discussed. [The relevance to hormonal cancer therapy is discussed.].