The synthesis of lipids in the livers of rats treated with pituitary growth hormone

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Abstract
The effect of administration of pituitary growth hormone on the rats of incorporation of C14 from pyruvate and acetate into CO2, fatty acids, phospholipids and cholesterol by rat-liver slices was investigated. There was no difference in the rate of production of CO2 from any of these substrates in normal or treated rats. The C14 of (carboxy-C14) pyruvate was only found in the CO2. Growth hormones reduced the rate of incorporation of C14 from ([alpha]-C14) pyruvate and (carboxy-C14) acetate into both fatty acids and phospholipids. The rate of incorporation of C14 into cholesterol appeared to be stimulated by growth hormone.