The mobilization of lipid by anterior pituitary growth hormone

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Abstract
The distr. of the lipids of liver and plasma of normal, adult, female rats, treated for differing periods of time with purified growth hormone, was investigated. Growth hormone causes a rapid mobilization of lipid to the liver, the peak of mobilization occurring 6 hrs. after treatment with the hormone. Transport to, and accumulation in, the liver is mainly a result of changes in the neutral fat fraction of the lipids. Cholesterol esters also may play a part in this mobilization. Evidence is presented that 6 hrs. after growth-hormone treatment, the synthesis of phos-pholipins by the liver is stimulated and that these are then released to the plasma. The values for various lipid fractions returned to the control level by 24 hrs. after growth-hormone treatment.