Alcohol Metabolism: Role of Microsomal Oxidation in vivo
- 31 October 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3905) , 627-628
- https://doi.org/10.1126/science.166.3905.627
Abstract
A role for microsomal alcohol oxidation cannot be demonstrated in vivo. Factors affecting microsomal drug hydroxylations had no effect on alcohol metabolism in the rat in vivo. The compound SKF 525-A which inhibits, and chronic phenobarbital treatment which enhances microsomal drug hydroxylations did not alter alcohol oxidation.Keywords
This publication has 5 references indexed in Scilit:
- Ethanol oxidation in the microsomal fraction of rat liverBiochemical and Biophysical Research Communications, 1969
- Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol FeedingScience, 1968
- Hepatic Microsomal Enzymes in Man and Rat: Induction and Inhibition by EthanolScience, 1968
- Ethanol Increases Hepatic Smooth Endoplasmic Reticulum and Drug-Metabolizing EnzymesScience, 1968
- Alcohol mixed function oxidase activity of mammalian liver microsomesBiochemical and Biophysical Research Communications, 1965