Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol Feeding
- 22 November 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 162 (3856) , 917-918
- https://doi.org/10.1126/science.162.3856.917
Abstract
Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol dehydrogenase. In vitro, it has characteristics comparable to those of microsomal drug-detoxifying enzymes and, in vivo, it is capable of adaptation to the administration of ethanol. The existence of this microsomal ethanol-oxidizing system may explain ultrastructural, pharmacological, and biochemical effects of ethanol.Keywords
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