Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6.YDom sex reversal
- 1 March 1994
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 6 (3) , 245-250
- https://doi.org/10.1038/ng0394-245
Abstract
Breeding the Y chromosome from certain Mus musculus domesticus strains onto the inbred laboratory mouse strain, C57BL/6J (B6), results in hermaphroditic progeny. This strain-dependent sex reversal suggests that there may be significant allelic variation in the murine sex determining gene, Sry. We have analysed the Sry genes from several domesticus-type Y chromosomes and show that they encode smaller proteins than the molossinus-type alleles SryB6 and Sry129. We have also identified a polymorphic stretch of trinucleotide repeats that is unique to strains causing sex reversal and show that specific changes in the predicted polyglutamine amino acid sequence at this site are associated with different degrees of sex reversal.Keywords
This publication has 28 references indexed in Scilit:
- Rapid evolution of the sex determining locus in Old World mice and ratsNature, 1993
- A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomesCell, 1993
- Nucleotide sequence of mouse Sry gene is different between Y chromosomes originating from Mus musculus musculus and Mus musculus domesticusGenomics, 1992
- The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structuresCell, 1992
- Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family memberPublished by Elsevier ,1992
- Male development of chromosomally female mice transgenic for SryNature, 1991
- A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motifNature, 1990
- Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding ProteinsScience, 1989
- Morphological development of the mouse gonad in tda-1 XY sex reversalDifferentiation, 1987
- Mus poschiavinus Y Chromosome in the C57BL/6J Murine Genome Causes Sex ReversalScience, 1982