Curculin, a sweet-tasting and taste-modifying protein, is a non-functional mannose-binding lectin
- 1 January 1997
- journal article
- research article
- Published by Springer Nature in Plant Molecular Biology
- Vol. 33 (4) , 691-698
- https://doi.org/10.1023/a:1005704616565
Abstract
A three-dimensional model of curculin, a sweet-tasting and taste-modifying protein from the fruits of Curculigo latifolia, was built from the X-ray coordinates of GNA, a mannose-binding lectin from snowdrop (Galanthus nivalis). The three mannose-binding sites present in GNA were found in curculin but are devoid of mannose-binding activity as shown by docking experiments performed with mannose. Some regions well exposed on the surface of the three-dimensional model of curculin could act as epitopes responsible for the sweet-tasting properties of this protein.Keywords
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