Effect of Heart Rate on Cardiac Membrane Potentials and the Unipolar Electrogram

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Abstract
Simultaneous records of the membrane action potential and unipolar electrogram of the papillary muscle demonstrate the direct dependence of the timing, polarity and magnitude of the T deflection of the electrogram on the time course of repolarization of the muscle membrane. A linear relationship between heart rate and the duration of electrical activity of the ventricle is demonstrated by single fiber recordings. The effect of cycle length on the duration of the plateau of ventricular action potential suggests the existence of an active delay of repolarization in cardiac muscle.

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