Thyrotoxicosis Occurring in Two Patients on Prolonged High Doses of Steroids

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Abstract
The suppressive effect of adrenocortical steroids on thyroid function is well documented in laboratory animals1 2 3 4 and in human beings.5 6 7 8 9 The relation of adrenocortical steroids and the thyroid gland has been comprehensively reviewed by Ingbar and Freinkel.9 The evidence presented suggests that short-term ACTH and cortisone administration suppress the hypophyseal secretion of thyroid-stimulating hormone (TSH). There are few experimental data utilizing long-term administration of these substances. The histologic data of Halmi and Barker10 present evidence of activation of rat thyroid glands as well as probable increased pituitary production of TSH.The following case reports of hyperthyroidism in patients on long-term, high-steroid . . .