Effects of Precurarization on the Blood Pressure and Heart Rate Changes Induced by Suxamethonium Facilitated Laryngoscopy and Intubation

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Abstract
The effects of precurarization on blood pressure [B.P.] and heart rate increases during laryngoscopy and intubation were studied in 60 surgical patients, who were randomly allocated to 4 groups, receiving as a pretreatment d-tubocurarine (0.05 mg/kg), alcuronium (0.03 mg/kg), pancuronium [skeletal muscle relaxants] (0.008 mg/kg) or saline in a double-blind fashion. d-Tubocurarine and alcuronium pretreatments seemed to attenuate the B.P. increase during laryngoscopy and intubation under suxamethonium. d-Tubocurarine pretreatment protected effectively against high B.P. increases. Heart-rate increases were of the same magnitude in all the pretreated groups. d-Tubocurarine pretreatment abolished suxamethonium-induced fasiculations completely, whereas alcuronium pretreatment gave protection in 93% and pancuronium pretreatment in 43% of patients.