Determination of 60 elements in whole blood by sector field inductively coupled plasma mass spectrometry
- 30 June 2000
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Analytical Atomic Spectrometry
- Vol. 15 (8) , 937-944
- https://doi.org/10.1039/b003561k
Abstract
A method is described for the determination of 60 elements in whole blood, using a double-focusing ICP-MS instrument. Microwave-assisted digestion in low-volume PFA vessels resulted in 10-fold sample dilution. External calibration with matrix-matched standards was used for quantification. Different factors affecting detection limits are discussed. The performance of the method for the determination of environmentally relevant concentrations was evaluated using a whole blood reference material and intercomparison samples. Owing to high instrumental detection power and low preparation blanks, 57 elements could be detected in the bovine whole blood reference material (IAEA A-13). Trace element leaching from commercially available blood sampling tubes made of glass was shown to be a serious contamination factor. Concentrations obtained for three calf blood samples taken under `metal-free' conditions are presented.Keywords
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