Carotid-cavernous sinus thrombosis caused by Aspergillus fumigatus

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Abstract
A [human] case is presented of A. fumigatus granuloma involving the sphenoid sinus, sella turcica, cavernous sinus and the internal carotid artery. The diagnosis was established by a transsphenoidal biopsy. The infection proved difficult to treat and finally remitted after chemotherapy with a combination of amphotericin B, rifampin (rifampicin) and flucytosine (5-fluorocytosine). The spectrum of aspergillosis of the CNS is reviewed and difficulties in treating this infection are considered.