K‐Opioid activity of the four stereoisomers of the peripherally selective κ‐agonists, EMD 60 400 and emd 61 753
- 1 January 1994
- Vol. 6 (8) , 685-689
- https://doi.org/10.1002/chir.530060814
Abstract
The four stereoisomers of the two peripherally selective κ‐opioid agonists EMD 60 400 and EMD 61 753 were synthesized, tested for stereoisomeric purity, and examined for affinity to the κ opioid receptor. The relationships between the configuration of these molecules and their biological activity are discussed.Keywords
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