TRANSFER OF AGE-ASSOCIATED RESTRAINED TUMOR-GROWTH IN MICE BY OLD-TO-YOUNG BONE-MARROW TRANSPLANTATION

  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (12) , 5677-5680
Abstract
B16 melanoma and Lewis lung carcinoma grow more slowly in aged mice. Immunesenescent changes may account for this age-related difference. The effect of immune deficiency on the growth of these tumors was tested by treating young mice with an immunosuppressive dose of radiation and then observing tumor growth. Young mice were irradiated to a higher (lethal) dose and then were rescued with either young or old bone marrow transfusion. Tumors grew more slowly in radiated mice than controls and in those reconstituted with old bone marrow. The concept of immunesenescent-related reduced tumor growth was thus supported.