Studies on Malaria in Chimpanzees

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Abstract
Summary The Madagascar strain of Plasmodium vivax was studied in two sporozoite-infected splenectomized chimpanzees. The parasitemia was high and the erythrocytic parasites were normal. First and second generations of exo-erythrocytic schizonts were demonstrated. The 8-day-old, premature, mature and burst preerythrocytic schizonts are described. The pre-erythrocytic generation of P. vivax completed its development in 7 days and some hours in the chimpanzee. The parasite was unchanged after passage through chimpanzees and was able to infect man.

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