Tumorigenicity of human bk papovavirus plaque isolates, wild-type and plaque morphology mutant, in hamsters

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Abstract
The polyoncogenic prototype human papovavirus BKV (Gardner''s strain) produced clear, small and large plaques. Two small-plaque isolates (wt-500 and wt-502), as well as a large-plaque-forming isolate (wt-501), induced frequent brain tumors and occasional osteosarcomas (but no insulinomas) in hamsters. The large-plaque former (wt-501) was more tumorigenic than the 2 small-plaque isolates. One small (pm-522) and 1 large turbid plaque mutant (pm-525), which had been rescued from hamster tumor cell lines and have small deletion near the origin of DNA replication, induced frequent brain tumors and insulinomas. Mutant 522 was .apprx. 5 times more tumorigenic than wt-501. The polyoncogenicity of prototype BKV is accounted for by the presence of BKV mutants.
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