Metabolism of the Transplanted Dog Kidney

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Abstract
Oxygen consumption and para-aminohippurate accumulation have been studied in slices of renal cortex from second-set kidney transplants in dogs. The organs were removed for evaluation 24 hours after transplantion, at a time when they show gross hemorrhagic reactions and reduced rates of urine secretion. In spite of advanced rejection, these second-set transplants still accumulated PAH in vitro to the same high level as autotransplant controls. Oxygen uptake also remained within normal limits. Further, the turnover of P in the acid and lipid soluble fractions remained unaffected by the acute rejection process. A small increase in the specific activity of the nucleic acid P was observed. We interpret these observations to indicate that cytotoxic reactions are not a major factor in transplant rejection. An interruption of the vascular supply, or a mechanical interference with the nutritional exchange of the tissue, are suggested as more likely causes of transplant destruction.

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